Age, sex, and race influence single-strand break repair capacity in a human population
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چکیده
منابع مشابه
Age, sex, and race influence single-strand break repair capacity in a human population.
Recently, we developed an improved comet assay protocol for evaluating single-strand break repair capacity (SSB-RC) in unstimulated cryopreserved human peripheral blood mononuclear cells (PBMCs). This methodology facilitates control of interexperimental variability [A.R. Trzeciak, J. Barnes, M.K. Evans, A modified alkaline comet assay for measuring DNA repair capacity in human populations. Radi...
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Single-strand break repair and genetic disease. DNA single-strand break repair SSBR is critical for the survival and. The association of human genetic disorders with defects in the DNA.encounter DNA single-strand breaks or other types of lesion. An inability to respond properly to, or to repair, DNA damage leads to genetic instability. Developmental disorders, Werner syndrome WS and Bloom syndr...
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ژورنال
عنوان ژورنال: Free Radical Biology and Medicine
سال: 2008
ISSN: 0891-5849
DOI: 10.1016/j.freeradbiomed.2008.08.031